The Effect of L –Thyroxine on Metabolic Parameters in Newly Diagnosed Primary Hypothyroidism

Objective: Thyroid hormones regulate the basal metabolic rates of most of the cell. This hospital based study was done to evaluate the metabolic changes induced in newly diagnosed hypothyroid patients and the benefits of early intervention in the same.Methodology: The study included 30 patients randomly selected from the department of endocrinology. Serum T3,T4,TSH, kidney function, total cholesterol levels were measured using standard kits. The same patients were revaluated after treatment with L-Thyroxine at the end of 6 months. Results: Hypothyroid patients showed decreases in Hb, increase in total cholesterol, serum uric acid and creatinine level compared to euthyroid patients. After 6 months of thyroxine treatment, Hb showed a significant increase (p<0.005), serum cholesterol(p<0.001),and serum uric acid level(p<0.001) showed a significant decrease, where as the serum creatinine level showed no significance(p<0.350). CONCLUSION: This shows that early intervention with thyroid replacement therapy resulted in reversible change in the metabolic parameters